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Page 1
Role of S100 and YKL40 on Intraventricular Cerebral Hemorrhages in the Preterm Infant and the Neuroprotective Role of miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 in Neonatal Mice with Nerve Injury.
Ijabi R, Kaminsky ZA, Roozehdar P, Ijabi J, Moradi-Sardareh H, Ling KH, Tehranian N. Ijabi R, et al. Curr Med Chem. 2023 Sep 15. doi: 10.2174/0929867331666230915103147. Online ahead of print. Curr Med Chem. 2023. PMID: 37724672
OBJECTIVE: In this research, we investigated how miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 affect apoptosis in hypoxic mice. METHODS: On the first and third days after delivery, the YKL40, HIF-1a, HVCN1, and S100b genes were compared between two groups of preter …
OBJECTIVE: In this research, we investigated how miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 affect apoptosis in hypoxic mice. METH …
pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.
Capasso M, DeCoursey TE, Dyer MJ. Capasso M, et al. Trends Cell Biol. 2011 Jan;21(1):20-8. doi: 10.1016/j.tcb.2010.09.006. Epub 2010 Oct 18. Trends Cell Biol. 2011. PMID: 20961760 Free PMC article. Review.
The importance of HVCN1 in pH regulation during phagocytosis was established by surprising evidence that indicated its first-responder role. In this review, we discuss recent findings from a functional perspective, and the potential of HVCN1 as a therapeutic target …
The importance of HVCN1 in pH regulation during phagocytosis was established by surprising evidence that indicated its first-responde …
Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells.
Coe D, Poobalasingam T, Fu H, Bonacina F, Wang G, Morales V, Moregola A, Mitro N, Cheung KC, Ward EJ, Nadkarni S, Aksentijevic D, Bianchi K, Norata GD, Capasso M, Marelli-Berg FM. Coe D, et al. JCI Insight. 2022 May 23;7(10):e147814. doi: 10.1172/jci.insight.147814. JCI Insight. 2022. PMID: 35472029 Free PMC article.
The increased expression of this channel in some cancers has led to proposing Hvcn1 antagonists as potential therapeutics. While its role in most leukocytes has been studied in depth, the function of Hvcn1 in T cells remains poorly defined. We show that Hvcn1 …
The increased expression of this channel in some cancers has led to proposing Hvcn1 antagonists as potential therapeutics. While its …
Regulation of immune responses by proton channels.
Capasso M. Capasso M. Immunology. 2014 Oct;143(2):131-7. doi: 10.1111/imm.12326. Immunology. 2014. PMID: 24890927 Free PMC article. Review.
The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how proton channels affect cellular functions. ...
The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how p …
Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels.
Okochi Y, Okamura Y. Okochi Y, et al. Int J Mol Sci. 2021 Mar 5;22(5):2620. doi: 10.3390/ijms22052620. Int J Mol Sci. 2021. PMID: 33807711 Free PMC article. Review.
Hv1/VSOP inhibits hypochlorous acid production by regulating degranulation, leading to reduced inflammation upon fungal infection, and suppresses the activation of extracellular signal-regulated kinase (ERK) signaling by inhibiting ROS production. ...
Hv1/VSOP inhibits hypochlorous acid production by regulating degranulation, leading to reduced inflammation upon fungal infection, an …
Duodenal-type and nodal follicular lymphomas differ by their immune microenvironment rather than their mutation profiles.
Hellmuth JC, Louissaint A Jr, Szczepanowski M, Haebe S, Pastore A, Alig S, Staiger AM, Hartmann S, Kridel R, Ducar MD, Koch P, Dreyling M, Hansmann ML, Ott G, Rosenwald A, Gascoyne RD, Weinstock DM, Hiddemann W, Klapper W, Weigert O. Hellmuth JC, et al. Blood. 2018 Oct 18;132(16):1695-1702. doi: 10.1182/blood-2018-03-837252. Epub 2018 Aug 20. Blood. 2018. PMID: 30126979 Free article.
Whole exome and targeted sequencing of DTFL revealed high mutation frequencies of EEF1A1 (35%) and HVCN1 (22%). We compared the immune microenvironment gene expression signatures of DTFL (n = 8) and LSTFL (n = 7). DTFL clearly separated from LSTFL by unsupervised, hierarch …
Whole exome and targeted sequencing of DTFL revealed high mutation frequencies of EEF1A1 (35%) and HVCN1 (22%). We compared the immun …
The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release.
Okochi Y, Aratani Y, Adissu HA, Miyawaki N, Sasaki M, Suzuki K, Okamura Y. Okochi Y, et al. J Leukoc Biol. 2016 Jan;99(1):7-19. doi: 10.1189/jlb.3HI0814-393R. Epub 2015 May 19. J Leukoc Biol. 2016. PMID: 25990245
On activation of NADPH oxidase by PMA and IgG, neutrophils derived from Hvcn1 gene knockout mouse exhibited greater secretion of MPO and elastase than WT cells. ...In addition, Hv1/VSOP-deficient mice exhibited more severe lung inflammation after intranasal Candida …
On activation of NADPH oxidase by PMA and IgG, neutrophils derived from Hvcn1 gene knockout mouse exhibited greater secretion of MPO …
Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells.
Hondares E, Brown MA, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D, Marelli-Berg F, Gribben JG, Dyer MJ, DeCoursey TE, Capasso M. Hondares E, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18078-83. doi: 10.1073/pnas.1411390111. Epub 2014 Nov 25. Proc Natl Acad Sci U S A. 2014. PMID: 25425665 Free PMC article.
HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. ...HVCN1 is expressed in malignant B cells that rely on BCR signaling, such as chronic lymphocytic leukemia (CLL) cells. ...
HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. ...HVCN1 is expressed in malignan …
Evaluation of genome-wide expression profiles of blood and sputum neutrophils in cystic fibrosis patients before and after antibiotic therapy.
Conese M, Castellani S, Lepore S, Palumbo O, Manca A, Santostasi T, Polizzi AM, Copetti M, Di Gioia S, Casavola V, Guerra L, Diana A, Montemurro P, Mariggiò MA, Gallo C, Maffione AB, Carella M. Conese M, et al. PLoS One. 2014 Aug 1;9(8):e104080. doi: 10.1371/journal.pone.0104080. eCollection 2014. PLoS One. 2014. PMID: 25084273 Free PMC article.
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would be sensitive to antibiotic therapy, we sought to evaluate the gene expression profiles of neutrophils in CF patients before treatment in comparison with non-CF healthy individuals …
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would be sensitive to antibiotic therapy, we …
11 results